Pipeline

Product Pipeline

Kezar’s complementary therapeutic platforms harness key regulators of cellular function and inhibit multiple drivers of disease, enabling the potential for significant clinical impact in the most difficult-to-treat diseases.

Both of Kezar's clinical candidates, KZR-616 and KZR-261, are first-in-class small molecule drugs. As a selective inhibitor of the immunoproteasome, KZR-616 has demonstrated broad immunomodulatory activity and has the potential to be an important new treatment for patients with autoimmune disease.  By targeting the activity of the Sec61 translocon, KZR-261 blocks many key proteins from entering the protein secretion pathway.  This results in several validated oncology targets being blocked with a single small molecule and speaks to the broad potential of this uniquely powerful new mechanism in both solid and hematologic tumor types.        

A First-in-Class Selective Immunoproteasome Inhibitor

A First-in-Class Selective Immunoproteasome Inhibitor

KZR-616

KZR-616 is designed to target a wide range of unmet needs in severe autoimmune diseases.

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A First-in-Class Sec61 Inhibitor

A First-in-Class Sec61 Inhibitor

KZR-261

KZR-261 is a broad-spectrum anti-tumor agent that acts through direct interaction and inhibition at the Sec61 translocon

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